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Research News

Site presented by Bill Tillier.

2018

Highlighted Research: Cytosolic.htm

(Because of the way articles come out, there is some overlap between years.)

Badrising, U. A., Tsonaka, R., Hiller, M., Niks, E. H., Evangelista, T., Lochmüller, H., . . . Spitali, P. (2017). Cytokine Profiling of Serum Allows Monitoring of Disease Progression in Inclusion Body Myositis. Journal of Neuromuscular Diseases, 4(4), 327-335.
Results: Ten cytokines (TRAIL, IL-8, MIF, MCP-1, LIF, IP-10, IFN-alpha2, MIG, bNGF and IL-3) were identified to be good to excellent markers to discern IBM patients from healthy controls. Three cytokines (IP-10, Eotaxin and SDF1A) changed significantly upon methotrexate treatment as compared with the natural clinical course. Muscle strength loss was associated with changes in IL-8 and SDF1A levels. IFN-gamma levels were only associated with survival of IBM patients before correction for multiple comparisons.
Discussion: Cytokine profiling can discriminate IBM patients from healthy controls and other neuromuscular disorders. Immunosuppression with methotrexate affects cytokine levels in IBM. IL-8 and SDF1A could serve as biomarkers for disease progression. https://doi.org/10.3233/JND-170234

Johari, M., Arumilli, M., Palmio, J., Savarese, M., Tasca, G., Mirabella, M., . . . Udd, B. (2017). Association study reveals novel risk loci for sporadic inclusion body myositis. European Journal of Neurology, 24(4), 572-577. https://doi.org/10.1111/ene.13244
Despite the challenges of sIBM being a complex disorder, genetic research is likely to result in important findings for understanding the etiology of the disease. Unusual combinations of different mutated genes in the same individual may result in a higher risk of developing a multifactorial sporadic disease like sIBM

Needham, M., & Mastaglia, F. (2017). Advances in inclusion body myositis: genetics, pathogenesis and clinical aspects. Expert Opinion on Orphan Drugs, 5(5), 431-443. https://doi.org/10.1080/21678707.2017.1318056

Dardis, C., Antezana, A., Tanji, K., & Maccabee, P. J. (2017). Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause. American Journal of Case Reports, 18, 700-706. https://doi.org/10.12659/AJCR.903566

Jorgensen, A. N., Aagaard, P., Nielsen, J. L., Christiansen, M., Hvid, L. G., Frandsen, U., & Diederichsen, L. P. (2017). Physical function and muscle strength in sporadic inclusion body myositis. Muscle & Nerve, 56(6), E50-E58. https://doi.org/10.1002/mus.25603

Alfano, L. N., Yin, H., Dvorchik, I., Maus, E. G., Flanigan, K. M., Mendell, J. R., & Lowes, L. P. (2017). Modeling functional decline over time in sporadic inclusion body myositis. Muscle & Nerve, 55(4), 526-531. https://doi.org/10.1002/mus.25373