Blood tests in making the diagnosis of inclusion body myositis.

Anti-cytosolic 5'-nucleotidase

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For an excellent summary see: https://cureibm.org/diagnosis/bloodtests/

Felice, K. J., Whitaker, C. H., Wu, Q., Larose, D. T., Shen, G., Metzger, A. L., & Barton, R. W. (2018). Sensitivity and clinical utility of the anti-cytosolic 5'-nucleotidase 1A (cN1A) antibody test in sporadic inclusion body myositis: report of 40 patients from a single neuromuscular center. Neuromuscular Disorders. https://doi.org/10.1016/j.nmd.2018.06.005
The anti-cN1A antibody test has limited diagnostic utility in IBM.

Greenberg, S. A. (2017). Inclusion Body Myositis Pathogenesis: Steady Progress. Annals of Neurology. http://doi.org/10.1002/ana.24920

Researchers' Work from Kumamoto University Focuses on Inclusion Body Myositis (Pathomechanisms of Anti-Cytosolic 5'-Nucleotidase 1A Autoantibodies in Sporadic Inclusion Body Myositis). (2017, May 26). Health & Medicine Week, 1234.


Tawara, N., Yamashita, S., Zhang, X., Korogi, M., Zhang, Z., Doki, T., . . . Ando, Y. (2017). Pathomechanisms of anti-cytosolic 5'-nucleotidase 1A autoantibodies in sporadic inclusion body myositis. Annals of Neurology, 81(4), 512-525. https://doi.org/10.1002/ana.24919

Liewluck, T. (2017). Anti-cytosolic 5'-nucleotidase 1A (cN1A) autoantibodies in motor neuron diseases. Neurology, 89(19), 2017-2018. https://doi.org/10.1212/WNL.0000000000004610

Lilleker, J. B., Rietveld, A., Pye, S. R., Mariampillai, K., Benveniste, O., Peeters, M. T. J., . . . van Engelen, B. G. M. (2017). Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis. Annals of the Rheumatic Diseases, 76(5), 862-868. https://doi.org/10.1136/annrheumdis-2016-210282

Herbert, M. K., Stammen-Vogelzangs, J., Verbeek, M. M., Rietveld, A., Lundberg, I. E., Chinoy, H., . . . Pruijn, G. J. M. (2016). Disease specificity of autoantibodies to cytosolic 5'-nucleotidase 1A in sporadic inclusion body myositis versus known autoimmune diseases. Annals of the Rheumatic Diseases, 75(4), 696-701. https://doi.org/10.1136/annrheumdis-2014-206691

Lloyd, T. E., Christopher-Stine, L., Pinal-Fernandez, I., Tiniakou, E., Petri, M., Baer, A., . . . Mammen, A. L. (2016). Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases. Arthritis Care & Research, 68(1), 66-71. https://doi.org/10.1002/acr.22600

Pluk, H., van Hoeve, B. J. a, van Dooren, S. H. J., Stammen-Vogelzangs, J., van der Heijden, A., Schelhaas, H. J., . . . Pruijn, G. J. M. (2013). Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis. Annals of Neurology, 73(3), 397-407. https://doi.org/10.1002/ana.23822

Larman, Benjamin, H., Salajegheh, M., Nazareno, R., Lam, T., Sauld, J., Steen, H., . . . Greenberg, S. A. (2013). Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Annals of Neurology, 73(3), 408-418. https://doi.org/10.1002/ana.23840